Hydrocodone for Restless Leg Syndrome

Hydrocodone is an opioid analgesic used to help relieve mild to moderate pain. Opioid analgesics lessen pain transmission to the brain by activating the descending nerve fibers from the periaqueductal gray. It is within the midbrain and raphe nuclei within the medulla that controls the endogenous opioid that has the dorsal horn of the spinal cord. Opioids inhibit directly afferent nerve transmission by binding to mu-opioid receptors postsynaptically and presynaptically within the dorsal horn of the spinal cord. As a result of mechanisms, the arising pathways for pain stimuli are reserved and pain relief is given to the patient. 

Things to know when taking Hydrocodone:

  • You may get dizzy or drowsy when you first take this drug. Do not use machinery, drive, or perform activities that may be hazardous until you know how this drug affects you. 
  • There are different types of pain medicine. If you take one type at the same time, you may have more side effects. Give your doctor or healthcare provider a list of all medicines you use. Your doctor will direct you on how much medicine to take. Do not take more medicine than prescribed. Call for medical help right away if you have signs of overdose. 
  • This drug will cause constipation. Try to have a bowel movement at least every 2-3 days if you do not have a bowel movement for 3 days, call your doctor immediately. 
  • It is not recommended to take medicines that contain Acetaminophen along with this drug. Excess intake of Acetaminophen can be very unsafe. 

Hydrocodone used for Restless Leg Syndrome

Lots of pharmacological interference is available for Restless Leg Syndrome such as drugs used to treat:

  • Epilepsy (anticonvulsants)
  • Parkinson’s disease (L-Dopa and dopaminergic agonists)
  • Pain (opioids)
  • Anxiety (benzodiazepines)

Dopaminergic medications are those most often used for the treatment of Restless Leg Syndrome, but various patients do not react effectively and need other medication. Opioids, a class of drugs used to treat severe pain, appear to be in effect for the treatment of the symptoms of Restless Leg Syndrome. They are also recommended for patients with severe symptoms because Restless Leg Syndrome and pain seem to share the same mechanism in the central nervous system. All available medications are linked to some degree with side effects, which might delay treatment. Opioids are related to opposing events such as dependence, tolerance, or constipation. This validates the conduct of a systematic review to determine whether opioids are safe and effective for the treatment of Restless Leg Syndrome.

Hydrocodone might cause possible side effects. Let your doctor know if any of these side effects are severe or do not go away:

  • Back pain
  • Headache
  • Stomach pain
  • Dry mouth
  • Uncontrollable shaking of a part of the body
  • Muscle tightening

Call for medical emergency assistance if you have any signs of overdose. Signs of overdose may include the following:

  • Sleepiness
  • Difficulty breathing
  • Muscle weakness
  • Slow or shallow breathing
  • Narrowed or widened pupils
  • Cold, clammy skin
  • Unable to respond or wake up
  • Slowed heartbeat

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