Naproxen and Omeprazole Prescribed Together

Naproxen and Omeprazole Prescribed Together

Naproxen and Omeprazole is a common drug prescription, especially in the UK. Both medications are individually used for the treatment of different illnesses. Conversely, several patients who are given Naproxen get Omeprazole at the same time.

Where is Naproxen used?

Naproxen is in the class of medications known as non-steroidal anti-inflammatory drugs (NSAIDs). This medicine is used for:

  • Onset gout
  • Pain and inflammation of musculoskeletal nature
  • Dysmenorrhea or painful period pains
  • Management of migraines

NSAIDs stop the production of prostaglandins which are the group of chemical that contributes to symptoms of pain and inflammation. Conversely, prostaglandins also have a broader role in the human body. Production of prostaglandins increases in response to infection or injury. By lessening the production of prostaglandins, NSAIDs lessens inflammation and pain.

Where is Omeprazole used?

Omeprazole is in the class of medications known as proton pump inhibitors (PPIs). PPIs are used mainly for the treatment of acid reflux and gastroesophageal reflux disease. Other uses may include:

  • Treatment of Helicobacter pylori along with a combination of two antibiotics
  • Treatment and prevention of gastric and duodenal ulcers
  • Zollinger-Ellison syndrome
  • Prevention of complications in patients who have a history of NSAID-associated duodenal, who take NSAIDs continuously, or who have gastric ulcers

Why are Naproxen and Omeprazole prescribed together?

Treatment with NSAIDs such as Naproxen is associated with several possible side effects. Some of the most common gastrointestinal side effects are along with Naproxen medication includes:

  • GI bleeding or perforation
  • Peptic ulcers
  • Dyspepsia
  • Heartburn
  • Abdominal discomfort

Prostaglandins have various roles in the body. Several prostaglandins are existent in the stomach lining. It is where they prevent acid secretion and stimulate mucus production. As a result, it has a protective role. Since Naproxen stops the production of prostaglandins, those who take the medicine are at higher risk of gastrointestinal complications such as ulcers, GI bleeding, and heartburn.

Proton pump inhibitors such as Omeprazole are prescribed along with Naproxen to reduce the stomach acid secretions and thus to lessen the risk of possible side effects.

Recommendation on the use of Omeprazole along with Naproxen

The official guideline recommends using Omeprazole when Naproxen is prescribed in patients who are at risk of gastrointestinal side effects. It is particularly those patients who need long-term treatment with NSAIDs who experience indigestion from standard NSAIDs such as Ibuprofen.

Patients who are at risk of side effects associated with the use of NSAIDs include:

  • With a history of stomach bleeds or ulcers
  • With a prescription of a high dose of NSAIDs
  • Patients aged over 65
  • Patients taking other medications that contribute to gastrointestinal side effects
  • Patients who drink alcohol or smoke a lot
  • Patients who require a long treatment with NSAIDs
  • Patients who experienced side effects with NSAIDs

Naproxen does not interact with Omeprazole. These two drugs can be taken at the same time. Naproxen and Omeprazole do not have to be co-prescribed to all patients. A particular group of at-risk patients’ needs Omeprazole treatment when Naproxen is recommended. In the UK, Naproxen must preferably be taken with food.

Leave a Reply