Pregabalin Effectively Treats Restless Leg Syndrome with Less Risk of Worsening Symptoms

What is Restless Leg Syndrome?

Restless Leg Syndrome is a condition in which you have an unpleasant sensation or feeling, usually in the calves of your legs that result in a strong, strong urge to move your legs.

  • The symptoms are worse in the evening or night and are typically brought on by rest.
  • Both legs might be affected or one may be worse than the other.
  • Movement such as stretching or walking brings relief for a short time, but the symptoms commonly return once you settle into a restful state.
  • Occasionally other parts of your body, such as your lower back or arms, may be affected.
  • Restless Leg Syndrome could affect your sleep and lead to feeling sleepy, tiredness, or trouble concentrating. If this happens, see your doctor and get help to manage your symptoms.

Most of the time, Restless Leg Syndrome can be diagnosed by your doctor or neurologist without any distinctive assessments. Conversely, blood tests might be obligatory to look for possible triggers.

If you have a medical condition that causes or worsens Restless Leg Syndrome, such as iron deficiency, treating it may resolve your symptoms. A change of medicine may be recommended if a side effect from a drug is thought to be responsible.

What is Pregabalin and where it is used?

Pregabalin is an antiepileptic drug also called an anticonvulsant. This is used for the treatment of pain that is caused by nerve damage because of diabetes or shingles infection. This medication is also used with other prescriptions to treat partial-onset seizures in children who are at least 1 month old and adults.

How does Pregabalin work?

Pregabalin binds to calcium channels found on nerve cells in the spinal cord and brain. This reduces the release of several neurotransmitters from these nerve cells. Neurotransmitters are involved in spreading messages between the nerve cells. This drug cuts the release of substance P, noradrenaline, and glutamate. Glutamate is out once electrical signals gather in nerve cells and then stimulates more nerve cells. It is thought to play a vital role in triggering epileptic seizures.  

Decreasing the release of glutamate from the nerve cells in the brain is thought to help stabilize the electrical activity in the brain and prevent epileptic fits. Noradrenaline, glutamate, and substance P are also involved in transmitting pain signals in the brain and nervous system. As Pregabalin decreases the release of these neurotransmitters, it can similarly use in nerve pain occurring because of nerve damage, or a disruption in the role of nerves.

Pregabalin and Restless Leg Syndrome

There is a certain study that shows significant therapeutic effects of Pregabalin on both motor and sensorial symptoms in Restless Leg Syndrome. Treatment with Pregabalin was linked with an improvement of periodic limb movements and sleep architecture. Opposing events included sleepiness and unsteadiness and must be screened sensibly in the working population, mainly when Pregabalin is administered in the afternoon. However, it is important to let your doctor know the medications you are taking especially for the treatment of Restless Leg Syndrome and other medical conditions.

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